874013-97-5Relevant articles and documents
Molecular modeling, design, synthesis, and biological activity of 1H-pyrrolo[2,3-c]pyridine-7-amine derivatives as potassium-competitive acid blockers
Arikawa, Yasuyoshi,Hasuoka, Atsushi,Hirase, Keizo,Inatomi, Nobuhiro,Sato, Fumihiko,Hori, Yasunobu,Takagi, Terufumi,Tarui, Naoki,Kawamoto, Makiko,Kajino, Masahiro
, p. 336 - 342 (2014)
A series of 1H-pyrrolo[2,3-c]pyridine-7-amine derivatives were designed and synthesized based on our docking model as potassium-competitive acid blockers (P-CABs). Molecular modeling of these derivatives led us to introduce a substituent at the 1-position
HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
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Page/Page column 70, (2012/12/13)
The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A' B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.