87406-01-7Relevant academic research and scientific papers
An I(I)/I(III) Catalysis Route to the Heptafluoroisopropyl Group: A Privileged Module in Contemporary Agrochemistry
Martín-Heras, Víctor,Daniliuc, Constantin G.,Gilmour, Ryan
, p. 4203 - 4212 (2021/06/02)
The heptafluoroisopropyl group is emerging as a privileged chemotype in contemporary agrochemistry and features prominently in the current portfolio of leading insecticides. To reconcile the expansive potential of this module with the synthetic challenges
A three-component synthesis of aryl(heteroaryl)acylamides
Loska, Rafa?,Bukowska, Patrycja
supporting information, p. 9872 - 9882 (2015/10/05)
A three-component reaction of azole or azine N-oxides, 1,1-difluorostyrenes and amines gives amides of α-aryl-α-heteroarylacetic or propionic acids. The key step is 1,3-dipolar cycloaddition between N-oxide and difluorostyrene leading to the acyl fluoride intermediate, which has been identified and characterized by NMR spectroscopy. The whole process is an example of selective functionalization of C-H bonds in both 5- and 6-membered heterocyclic systems.
THE SYNTHESIS OF ANTIINFLAMMATORY &α-(TRIFLUOROMETHYL)ARYLACETIC ACIDS
Middleton, W. J.,Bingham, E. M.
, p. 561 - 574 (2007/10/02)
Several novel α-trifluoromethylarylacetic acids were synthesized, utilizing chloropentafluoroacetone as the source of the trifluoromethyl group.One of these new acids, the trifluoro-analog (30) of ibuprofen, showed antiinflammatory, analgesic, and ulcerogenic properties similar to ibuprofen.
