22796-16-3

Upstream product

• 87406-01-7 1,1,3,3,3-pentafluoro-2-<4-(1,1-dimethylethyl)phenyl>propene 
• 73471-97-3 1-(4-(tertbutyl)phenyl)-2,2,2-trifluoroethanone 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 116-15-4 perfluoropropylene 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 22796-15-2 1,1,1,3,3,3-hexafluoro-2-(4-tert-butylphenyl)-2-propanol 

Relevant academic research and scientific papers

An I(I)/I(III) Catalysis Route to the Heptafluoroisopropyl Group: A Privileged Module in Contemporary Agrochemistry

The heptafluoroisopropyl group is emerging as a privileged chemotype in contemporary agrochemistry and features prominently in the current portfolio of leading insecticides. To reconcile the expansive potential of this module with the synthetic challenges

Regiocontrolled Heptafluoroisopropylation of Aromatic Halides by Copper(I) Carboxylates with Heptafluoroisopropyl-Zinc Reagents

Copper(I)-mediated heptafluoroisopropylation of aryl halides (ArX: X = I, Br) is demonstrated using copper(I) carboxylates and a bis(heptafluoroisopropyl)zinc reagent Zn(i-C3F7)2(dmf)2, prepared from heptafluoroisopropyl iodide and diethylzinc. The air-tolerant solid heptafluoroisopropylzinc reagent is advantageous to conduct simple synthetic operations and successful to give the corresponding heptafluoroisopropyl arene derivatives via transmetalation to copper(I) center. The newly developed copper(I)-mediated heptafluoroisopropylation process can be advanced to the copper(I)-catalysis by silver carboxylate salts and complementary to the precedent radical-based processes.

A hexafluoropropylene directly to the aryl borate method of oxidation heptafluoro isopropylation

The invention relates to a method for directly oxidizing arylboronic acid into heptafluoroisopropyl by utilizing hexafluoropropylene. The method comprises the following steps that silver fluoride is used as a fluorine source, under the effect of copper salt, the hexafluoropropylene and the arylboronic acid can be converted into a series of compounds containing heptafluoroisopropyl in organic solvents at the room temperature, and the reaction is also applicable to alkenylboronic acids. The method has the advantage that a series of compounds containing the heptafluoroisopropyl are synthesized through one-step reaction at high selectivity.

Direct heptafluoroisopropylation of arylboronic acids via hexafluoropropene (HFP)

A novel and straightforward strategy for heptafluoroisopropylation of arylboronic acids at room temperature has been developed. This method, directly using commercial available hexafluoropropene (HFP) as the starting material, provides a new way to synthesize a variety of synthetically useful heptafluoroisopropylated arenes.