87408-08-0

Upstream product

• 87408-06-8 (S)-5-[(1R,5R)-6-((R)-1-Benzhydryloxycarbonyl-2-methyl-propyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-3-yl]-2-tert-butoxycarbonylamino-pentanoic acid benzhydryl ester 
• 87408-06-8 (S)-5-[(1S,5S)-6-((R)-1-Benzhydryloxycarbonyl-2-methyl-propyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-3-yl]-2-tert-butoxycarbonylamino-pentanoic acid benzhydryl ester 
• 87408-06-8 5-[(1R,5R)-6-((R)-1-Benzhydryloxycarbonyl-2-methyl-propyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-3-yl]-2-tert-butoxycarbonylamino-pentanoic acid benzhydryl ester 

Relevant academic research and scientific papers

SYNTHESIS OF 1-(1-D-CARBOXY-2-METHYLPROPYL)-3-L-(5-L-AMONOADIPAMIDO)-4-L-MERCAPTOAZETIDIN-2-ONE (SECO-ISOPENICILLIN N), A POTENTIAL INTERMEDIATE IN PENICILLIN BIOSYNTHESIS.

The title compound has efficiently been synthesized by the skeletal rearrangement of the protected isopenicillin N sulfoxide and the subsequent hydrolysis of the thiazoline ring.

CONCERNING THE INTERMEDIACY OF MONOCYCLIC β-LACTAMS IN PENICILLIN BIOSYNTHESIS: SYNTHESIS AND ATTEMPTED BIOCONVERSION OF SECO-ISOPENICILLIN N

The title compound (3a) was synthesized as its dimer by the skeletal rearrangement of protected isopenicillin N-sulfoxide, hydrogenation, hydrolysis of the thiazoline ring, oxidative dimerization and deprotection.The reductive conversion of the dimer to m