SYNTHESIS OF 1-(1-D-CARBOXY-2-METHYLPROPYL)-3-L-(5-L-AMONOADIPAMIDO)-4-L-MERCAPTOAZETIDIN-2-ONE (SECO-ISOPENICILLIN N), A POTENTIAL INTERMEDIATE IN PENICILLIN BIOSYNTHESIS.

Article abstract of DOI:10.1016/S0040-4039(00)88064-8

The title compound has efficiently been synthesized by the skeletal rearrangement of the protected isopenicillin N sulfoxide and the subsequent hydrolysis of the thiazoline ring.