87408-15-9Relevant academic research and scientific papers
Stereoselective synthesis and preliminary evaluation of new D-3-heteroarylcarbonylalanines as ligands of the NMDA receptor
Lima, Paulo G.,Caruso, Rodrigo R.B.,Alves, Simone O.,Pess?a, Renata F.,Mendon?-Silva, Dayde L.,Nunes, Ricardo J.,No?l, Fran?ois,Castro, Newton G.,Costa, Paulo R.R.
, p. 4399 - 4403 (2004)
New N-heteroarylcarbonylalanines of the d-series were stereoselectively prepared from enoates derived from d-mannitol. Their activities in binding and functional assays for the NMDA sub-type of glutamate receptors are described. New N-heteroarylcarbonylal
Synthesis of β-amino arylketones through the addition of ArLi derivatives to β-aminoesters
Lima, Paulo G.,Sequeira, Lucia C.,Costa, Paulo R.R.
, p. 3525 - 3527 (2007/10/03)
2-Lithiumthiophene and 2-lithiumpyridine were allowed to react with N-substituted β-aminoesters. Only β-amino arylketones were obtained from N-BOC, N-H derivatives, while arylenoates were formed (retro-conjugate addition) from those substrates bearing N-Bn, N-H substituents, despite the aryllithium used. When the nitrogen is disubstituted (BOC and Bn), the product distribution depended on the nucleophile, leading to tertiary alcohols for 2-lithiumthiophene or ketones for 2-lithiumpyridine. Tertiary alcohols were also formed when PhLi was used as a nucleophile.
Chemistry of O-Silylated Ketene Acetals: Stereocontrolled Synthesis of 3-Benzoylamino-2,3-dideoxypentoses by a 1,3-Addition to Chiral Nitrones
Kita, Yasuyuki,Tamura, Osamu,Itoh, Fumio,Kishino, Hiroko,Miki, Takashi,et al.
, p. 2002 - 2007 (2007/10/02)
The stereochemistry of 1,3-addition of ketene acetals (1a,b) to the chiral nitrones (4a-d) derived from 2,3-O-isopropylidene-D-glyceraldehyde was examined.The reaction of ketene methyl tert-butyldimethylsilyl acetal (1a) with the N-benzylnitrone (4a) prod
Ketene Silyl Acetal Chemistry; Diastereofacial Selectivity of 1,3-Addition of Chiral Nitrones
Kita, Yasuyuki,Tamura, Osamu,Itoh, Fumio,Kishino, Hiroko,Miki, Takashi,et al.
, p. 761 - 763 (2007/10/02)
The reaction of dimethyl-t-butylsiloxy-1-methoxyethene (1a) with the N-benzylnitrone (3a) produced the syn-1,3-adduct (4a) predominantly, while the reaction of dimethyl-t-butylsiloxy-1-t-butoxyethene (1b) with the N-diphenylmethylnitrone (3d) gave the ant
ENANTIOSELECTIVE SYNTHESIS OF (R)- AND (S)-4--2-AZETIDINONES FROM D-GLYCERALDEHYDE ACETONIDE
Matsunaga, Hiroshi,Sakamaki, Tomoko,Nagaoka, Hiroto,Yamada, Yasuji
, p. 3009 - 3012 (2007/10/02)
(R)-N-Benzyl-4--2-azetidinone (10) and (S)-4--2-azetidinone (17) were enantioselectively synthesized from the benzylamino ester 3, which was prepared by the highly stereoselective 1,4-addition of benzylami
