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874143-67-6

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874143-67-6 Usage

Chemical compound

6-Chloro-N-(2-pyridinylmethyl)-2-pyrazinamine

Classification

Pyrazinamine derivative

Structural features

Pyridine-containing compound with a chlorine atom attached to the sixth carbon of the pyrazine ring

Pharmaceutical applications

Potential use in the treatment of tuberculosis, similar to pyrazinamide

Biological interactions

Presence of a pyridine moiety suggests potential interactions with biological systems and pharmaceutical targets

Potential for further study

Molecule of interest for further research and development in pharmaceutical applications

Check Digit Verification of cas no

The CAS Registry Mumber 874143-67-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,1,4 and 3 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 874143-67:
(8*8)+(7*7)+(6*4)+(5*1)+(4*4)+(3*3)+(2*6)+(1*7)=186
186 % 10 = 6
So 874143-67-6 is a valid CAS Registry Number.

874143-67-6Downstream Products

874143-67-6Relevant articles and documents

Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead

Niculescu-Duvaz, Ion,Roman, Esteban,Whittaker, Steven R.,Friedlos, Frank,Kirk, Ruth,Scanlon, Ian J.,Davies, Lawrence C.,Niculescu-Duvaz, Dan,Marais, Richard,Springer, Caroline J.

, p. 407 - 416 (2006)

B-RAF, a serine/threonine kinase, plays an important role in the development of certain classes of cancer, especially melanoma. As a result of high-throughput screening of a 23,000 compound library, 2-(3,4,5- trimethoxyphenylamino)-6-(3-acetamidophenyl)pyrazine, 1, was identified as a low micromolar (IC50 = 3.5 μM) B-RAF inhibitor. This compound was chosen as the starting point of a program aimed at producing potent inhibitors of B-RAF. We have synthesized a series of 40 novel compounds, which involved extensive modifications to the 2-(3,4,5-trimethoxyphenylamino) moiety (ring A) of 1. Their biological profiles against isolated B-RAF and mutated B-RAF in a cellular assay have been determined. These efforts led to the identification of two compounds exhibiting activities lower than 800 nM against B-RAF.

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