874208-94-3

Usage

Uses

Used in Bioconjugation:
MPEG4-NHS is used as a bioconjugation agent for attaching proteins, peptides, or other amine-containing molecules to various surfaces or supports. The NHS ester reacts with primary amines to form stable amide bonds, facilitating the covalent attachment of biomolecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, MPEG4-NHS is used as a component in drug delivery systems. The PEG spacer improves the solubility and stability of drug molecules, while the NHS ester allows for the attachment of therapeutic agents to carriers or nanoparticles.
Used in Diagnostics:
MPEG4-NHS is utilized in the development of diagnostic tools, such as imaging agents or biosensors. The PEG linker can be attached to contrast agents or signaling molecules, enhancing their solubility and biocompatibility.
Used in Research:
In research settings, MPEG4-NHS serves as a valuable reagent for the modification of amine-containing molecules. It enables the creation of novel conjugates for studying protein-protein interactions, enzyme activity, or other biological processes.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 81836-43-3 2,5,8,11,14-pentaoxaheptadecan-17-oic acid 

Relevant academic research and scientific papers

Towards Dual-Functionality Spin-Crossover Complexes

The multistep synthesis of a versatile new 4-substituted 3,5-bis(2-pyridyl)-1,2,4-triazole (Rdpt) ligand, 4-[4-(2-aminomethyl)phenyl]-3,5-bis(2-pyridyl)-4 H-1,2,4-triazole (apdpt), is reported, which features a reactive aminomethyl para-substituent on the phenyl group that points “out of the back” of the triazole. This enables further functionalisation under mild conditions by using a range of esters to form an amide link. Specifically, this proof of principle study demonstrates the synthesis of apdpt successfully appended with gold-binding thioctic acid (tpdpt), graphene-binding/emissive pyrene/propylpyrene (prdpt/pbdpt), and a Langmuir–Blodgett film-forming polyethylene glycol (PEG) tail (pgdpt). These ligands are subsequently reacted with [Fe(pyridine)4(NCBH3)2] to give the mononuclear iron(II) complexes [Fe(Rdpt)2(NCBH3)2]?solvent, in which Rdpt/solvent is tpdpt/2.5 H2O (1), prdpt/0.5 CHCl3?H2O (2), and pbdpt/0.5 CHCl3?2 H2O (3), as red powders. Magnetic studies on these powders indicate that the complexes undergo only very gradual and incomplete spin crossover, from completely or mostly high spin at 300 K, to half or three-quarters high spin at 50 K. Gold nanoparticles are successfully functionalised with the thioctic acid tpdpt ligand to give tpdpt@Au with an average diameter (as determined by TEM) of (3.1±0.7) nm. Preliminary studies on the two pyrene systems in dimethylformamide show that upon excitation at λ=345 nm the blue fluorescence observed for the free ligands is retained, essentially unaffected, in the respective complexes.

Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof

Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular, the invention provides a solid pharmaceutical composition