874212-65-4Relevant academic research and scientific papers
3,4-Disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity
Setti, Eduardo L.,Davis, Dana,Janc, James W.,Jeffery, Douglas A.,Cheung, Harry,Yu, Walter
, p. 1529 - 1534 (2005)
The synthesis of a series of highly potent and selective inhibitors of cathepsin K based on the 3,4-disubstituted azetidin-2-one warhead is reported. A high degree of potency and selectivity was achieved by introducing a basic nitrogen into the distal par
