87423-61-8

Basic information

• Product Name: 1H-Indole-2,3-dione, 5-fluoro-1-(4-fluorophenyl)-
• Synonyms: 1-(4-Fluorophenyl)-5-fluoroisatin;1H-Indole-2,3-dione,5-fluoro-1-(4-fluorophenyl);5-Fluoro-1-(4-fluorophenyl)isatin
• CAS NO: 87423-61-8
• Molecular Formula: C14H7F2NO2
• Molecular Weight: 259.212
• Mol File: 87423-61-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 180-190 °C
• Boiling Point: 416.1±55.0 °C(Predicted)
• Density: 1.479±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Indole-2,3-dione, 5-fluoro-1-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2,3-dione, 5-fluoro-1-(4-fluorophenyl)-(87423-61-8)
• EPA Substance Registry System: 1H-Indole-2,3-dione, 5-fluoro-1-(4-fluorophenyl)-(87423-61-8)

Safety Data

• Hazardous Substances Data: 87423-61-8(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 330-91-6 bis-(4-fluoro-phenyl)-amine 

Downstream Products

• 106516-03-4 5-Fluoro-1-(4-fluoro-phenyl)-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole 
• 138900-19-3 1-(4-fluorophenyl)-5-fluoro-1H-indole 

Relevant articles and documents

A Novel Class of "GABAergic" Agents: 1-Aryl-3-(aminoalkylidene)oxindoles

Antagonism of mercaptopropionic acid (MPA) induced convulsions, reflecting a GABAergic mechanism, was observed in a series of 1-aryl-3-(aminoalkylidene)oxindoles.Optimal MPA antagonism was associated with 3-halo, 3-alkyl, and/or 4-alkoxy substituents in the pendant aryl ring and with (dimethylamino)methylene, 1-(dimethylamino)ethylidene and N-methyl-2-pyrrolidinylidene side chains.The precise mechanism of action of these agents is unclear at this time; however, they are not GABA mimics and they do not affect GABA levels.Like other GABAergic agents, these compounds are potent enhancers of benzodiazepine binding and they antagonize cyclic GMP elevations induced by isoniazid.Compounds from this series may therefore have potential therapeutic utility as anticonvulsants or anxiolytics.