87427-94-9Relevant academic research and scientific papers
Microwave-Assisted Ruthenium-Catalysed ortho-C?H Functionalization of N-Benzoyl α-Amino Ester Derivatives
Sharma, Nandini,Bahadur, Vijay,Sharma, Upendra K.,Saha, Debasmita,Li, Zhenghua,Kumar, Yogesh,Colaers, Jona,Singh, Brajendra K,Van der Eycken, Erik V.
supporting information, p. 3083 - 3089 (2018/08/24)
A microwave-assisted highly efficient intermolecular C?H functionalization sequence has been developed to access substituted isoquinolones using α-amino acid esters as a directing group. This methodology enables a wide range of N-benzoyl α-amino ester derivatives to react via a Ru-catalysed C?H bond activation sequence, to form isoquinolones with moderate to excellent yields. As an additional advantage, our strategy proved to be widely applicable and also enabled the reaction of alkenes to provide access to alkenylated benzamides. The methodology was also extended towards the synthesis of isoquinoline alkaloids derivatives viz. oxyavicine and a dipeptide. The developed protocol is simple and cheap, avoids tedious workup procedures and works efficiently under MW irradiation. (Figure presented.).
Inhibitors of bacterial cystathionine β-lyase: Leads for new antimicrobial agents and probes of enzyme structure and function
Ejim, Linda J.,Blanchard, Jan E.,Koteva, Kalinka P.,Sumerfield, Rachael,Elowe, Nadine H.,Chechetto, Jonathan D.,Brown, Eric D.,Junop, Murray S.,Wright, Gerard D.
, p. 755 - 764 (2007/10/03)
The biosynthesis of methionine is an attractive antibiotic target given its importance in protein and DNA metabolism and its absence in mammals. We have performed a high-throughput screen of the methionine biosynthesis enzyme cystathionine β-lyase (CBL) a
An efficient one-pot synthesis of hippuric acid ethyl ester derivatives
Conway, Samuel C.,Perni, Robert B.
, p. 1539 - 1545 (2007/10/03)
A rapid, one-pot procedure is described for the preparation of the ethyl esters of a number of ring-substituted N-benzoyl glycine (hippuric acid) derivatives from readily-available starling materials.
