874290-93-4 Usage
Uses
Used in Pharmaceutical Synthesis:
4-[(DIMETHYLCARBAMOYL)AMINO]BENZENEBORONIC ACID, PINACOL ESTER 95% and 4-(3-DIMETHYLUREIDO)BENZENEBORONIC ACID, PINACOL ESTER are used as intermediates in the synthesis of pharmaceuticals for their ability to form carbon-carbon bonds through Suzuki-Miyaura coupling reactions. This allows for the creation of complex molecular structures that are essential in developing new drugs with improved therapeutic properties.
Used in Agrochemical Synthesis:
In the agrochemical industry, these Boronic acid pinacol esters are utilized as intermediates in the synthesis of agrochemicals, contributing to the development of effective pesticides, herbicides, and other crop protection agents. Their role in forming carbon-carbon bonds enables the production of novel and efficient agrochemical compounds.
Used in Materials Science:
4-[(DIMETHYLCARBAMOYL)AMINO]BENZENEBORONIC ACID, PINACOL ESTER 95% and 4-(3-DIMETHYLUREIDO)BENZENEBORONIC ACID, PINACOL ESTER are employed in materials science for the synthesis of advanced materials with unique properties. Their ability to form carbon-carbon bonds through Suzuki-Miyaura coupling reactions allows for the development of new materials with improved performance in various applications, such as electronics, energy storage, and nanotechnology.
Used in Polymer Chemistry:
In the field of polymer chemistry, these Boronic acid pinacol esters are used as monomers or intermediates in the synthesis of polymers with specific properties. Their involvement in forming carbon-carbon bonds enables the creation of polymers with tailored characteristics, such as enhanced mechanical strength, thermal stability, or specific chemical reactivity.
Overall, 4-[(DIMETHYLCARBAMOYL)AMINO]BENZENEBORONIC ACID, PINACOL ESTER 95% and 4-(3-DIMETHYLUREIDO)BENZENEBORONIC ACID, PINACOL ESTER are versatile compounds with a wide range of applications in various industries, including pharmaceuticals, agrochemicals, materials science, and polymer chemistry. Their role in facilitating carbon-carbon bond formation through Suzuki-Miyaura coupling reactions makes them valuable reagents in the synthesis of complex molecules and advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 874290-93-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,2,9 and 0 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 874290-93:
(8*8)+(7*7)+(6*4)+(5*2)+(4*9)+(3*0)+(2*9)+(1*3)=204
204 % 10 = 4
So 874290-93-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H23BN2O3/c1-14(2)15(3,4)21-16(20-14)11-7-9-12(10-8-11)17-13(19)18(5)6/h7-10H,1-6H3,(H,17,19)
874290-93-4Relevant academic research and scientific papers
Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 6-aryl substituent
Verheijen, Jeroen C.,Richard, David J.,Curran, Kevin,Kaplan, Joshua,Lefever, Mark,Nowak, Pawel,Malwitz, David J.,Brooijmans, Natasja,Toral-Barza, Lourdes,Zhang, Wei-Guo,Lucas, Judy,Hollander, Irwin,Ayral-Kaloustian, Semiramis,Mansour, Tarek S.,Yu, Ker,Zask, Arie
supporting information; experimental part, p. 8010 - 8024 (2010/07/04)
Design and synthesis of a series of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d] pyrimidines as potent and selective inhibitors of the mammalian target of rapamycin (mTOR) are described. Optimization of the 6-aryl substituent led to the discovery of inhibitors carrying 6-ureidophenyl groups, the first reported active site inhibitors of mTOR with subnanomolar inhibitory concentrations. The data presented in this paper show that 6-arylureidophenyl substituents led to potent mixed inhibitors of mTOR and phosphatidylinositol 3-kinase α (PI3K-α), whereas 6-alkylureidophenyl appendages gave highly selective mTOR inhibitors. Combination of 6-alkylureidophenyl groups with 1-carbamoylpiperidine substitution resulted in compounds with subnanomolar IC50 against mTOR and greater than 1000-fold selectivity over PI3K-α. In addition, structure based drug design resulted in the preparation of several 6-arylureidophenyl-1H-pyrazolo[3,4-d]pyrimidines, substituted in the 4-position of the arylureido moiety with water solubilizing groups. These compounds combined potent mTOR inhibition (IC50501 nM). 2009 American Chemical Society.
