874338-27-9Relevant academic research and scientific papers
Rapid Assembly of Diversely Functionalized Spiroindenes by a Three-Component Palladium-Catalyzed C?H Amination/Phenol Dearomatization Domino Reaction
Fan, Liangxin,Liu, Jingjing,Bai, Lu,Wang, Yaoyu,Luan, Xinjun
, p. 14257 - 14261 (2017)
A novel palladium-catalyzed three-component reaction of phenol-derived biaryls with N-benzoyloxyamines and norbornadiene (NBD) has been developed for the assembly of highly functionalized spiroindenes. This domino process was realized through NBD-assisted C?H amination and phenol dearomatization by forming one C?N bond and two C?C bonds in a single step. Preliminary studies indicated that asymmetric control of this transformation was feasible with chiral ligands. Moreover, the potential synthetic utility of this methodology was highlighted by a series of further transformations.
Synthesis of naphthalenes and 2-naphthols by the electrophilic cyclization of alkynes
Zhang, Xiaoxia,Sarkar, Sampa,Larock, Richard C.
, p. 236 - 243 (2007/10/03)
A wide variety of substituted naphthalenes are readily prepared regioselectively under mild reaction conditions by the 6-endo-dig electrophilic cyclization of appropriate arene-containing propargylic alcohols by IC1, I 2, Br2, NBS, and PhSeBr. 3-Iodo-2-naphthols have also been prepared in excellent yields by the cyclization of analogous 1-aryl-3-alkyn-2-ones. This methodology readily accommodates various functional groups and has been successfully extended to the synthesis of substituted carbazoles and dibenzothiophenes.
