20191-75-7

Basic information

• Product Name: 2-AMINO-1-BROMONAPHTHALENE
• Synonyms: 2-AMINO-1-BROMONAPHTHALENE;1-bromonaphthalen-2-amine
• CAS NO: 20191-75-7
• Molecular Formula: C₁₀H₈BrN
• Molecular Weight: 222.08
• EINECS: 202-080-4
• Mol File: 20191-75-7.mol
• Article Data: 26

Chemical Properties

• Melting Point: 63-64 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 345.5°C at 760 mmHg
• Flash Point: 162.8°C
• Appearance: /
• Density: 1.563g/cm³
• Vapor Pressure: 6.12E-05mmHg at 25°C
• Refractive Index: 1.718
• PKA: 1.51±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-1-BROMONAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-1-BROMONAPHTHALENE(20191-75-7)
• EPA Substance Registry System: 2-AMINO-1-BROMONAPHTHALENE(20191-75-7)

Safety Data

• Hazardous Substances Data: 20191-75-7(Hazardous Substances Data)

Usage

General Description

2-Amino-1-bromonaphthalene is a chemical compound with the formula C10H9BrN. It is a brominated derivative of naphthalene, and it contains a bromine atom and an amino group. 2-AMINO-1-BROMONAPHTHALENE is used in the synthesis of various organic molecules and can be employed as a building block for the production of pharmaceuticals, dyes, and other specialty chemicals. It is also utilized in research laboratories as a reagent for various organic reactions. However, it is important to handle 2-amino-1-bromonaphthalene with caution, as it may pose hazards to the environment and human health.

InChI:InChI=1/C10H8BrN/c11-10-8-4-2-1-3-7(8)5-6-9(10)12/h1-6H,12H2

Upstream product

• 77-48-5 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione 
• 91-59-8 naphthalen-2-ylamine 
• 18271-18-6 N-(2-naphthyl)-p-toluenesulphonamide 
• 5043-27-6 3-amino-4-bromo-2-naphthoic acid 
• 81-16-3 2-aminonaphthalenesulfonic acid 
• 612-52-2 2-naphthylamine hydrochloride 
• 93-09-4 naphthalene-2-carboxylate 
• 454713-45-2 naphthalen-2-yl-carbamic acid tert-butyl ester 
• 5959-52-4 2-Amino-3-naphthoic acid 
• 856074-57-2 4-bromo-3-(toluene-4-sulfonylamino)-[2]naphthoic acid 
• 60178-65-6 3-((4-methylphenyl)sulfonamido)-2-naphthoic acid 
• 581-97-5 2-acetylaminonaphthalene 
• 93-08-3 methyl 2-naphthyl ketone 
• 20937-86-4 2-azidonaphthalene 

Downstream Products

• 666856-03-7 2-(1-bromo-[2]naphthylamino)-4-chloro-benzoic acid 
• 875844-31-8 N-(1-bromo-[2]naphthyl)-benzenesulfonamide 
• 85-02-9 benzo[f]quinoline 
• 137840-33-6 2-[(1-Bromo-naphthalen-2-ylcarbamoyl)-methyl]-benzoic acid 
• 342-55-2 1-bromo-2-fluoro-naphthalene 
• 91-59-8 naphthalen-2-ylamine 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 63077-00-9 12,13-dihydro-7H-dibenzo[a,g]carbazole 

Relevant articles and documents

Axially Chiral Dibenzazepinones by a Palladium(0)-Catalyzed Atropo-enantioselective C?H Arylation

Atropo-enantioselective C?H functionalization reactions are largely limited to the dynamic kinetic resolution of biaryl substrates through the introduction of steric bulk proximal to the axis of chirality. Reported herein is a highly atropo-enantioselective palladium(0)-catalyzed methodology that forges the axis of chirality during the C?H functionalization process, enabling the synthesis of axially chiral dibenzazepinones. Computational investigations support experimentally determined racemization barriers, while also indicating C?H functionalization proceeds by an enantio-determining CMD to yield configurationally stable eight-membered palladacycles.

KRAS G12D INHIBITORS

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Atroposelective Synthesis of Conjugated Diene-Based Axially Chiral Styrenes via Pd(II)-Catalyzed Thioether-Directed Alkenyl C-H Olefination

The efficient stereoselective synthesis of conjugated dienes, especially those with axial chirality, remains a great challenge. Herein, we report the highly atroposelective synthesis of axially chiral styrenes with a conjugated 1,3-diene scaffold via a Pd(II)-catalyzed thioether-directed alkenyl C-H olefination strategy. This strategy features easy operation, mild reaction conditions, high functional group tolerance (69 examples), complete Z-selectivity, and excellent enantioselectivities (up to 99% ee). Notably, the highly enantioselective synthesis of atropisomers with two stereogenic axes were also achieved using this strategy (up to 99% ee and 97:3 dr). Moreover, the reaction could be scaled up, and the resulting axially chiral styrenes could be easily oxidized into chiral sulfoxide derivatives with high diastereoselectivities, which showed great promise as a new type of sulfur-olefin ligand.