874338-71-3

Upstream product

• 931-49-7 1-ethenylcyclohexene 
• 95092-10-7 N-methoxy-N-methyl-2-phenylacetamide 
• 122-78-1 phenylacetaldehyde 
• 874338-34-8 4-(cyclohex-1-enyl)-1-phenylbut-3-yn-2-ol 

Relevant academic research and scientific papers

Gold-Catalyzed Synthesis of Chiral Cyclopentadienyl Esters via Chirality Transfer

Efficient access to chiral cyclopentadienyl esters from readily accessible chiral enynyl ester substrates is developed. Typically high levels of chirality transfer realized in this homogeneous gold catalysis are attributed to the intermediacy of a chiral bent allene gold complex. Cyclopentadienyl esters can be prepared in good yields and with excellent enantiomeric excesses. The synthetic utilities of the chiral cyclopentadienyl esters are demonstrated by the Diels-Alder reactions, fluorination, alkylation, and epoxidation without any notable erosion of enantiopurity.

Synthesis of naphthalenes and 2-naphthols by the electrophilic cyclization of alkynes

A wide variety of substituted naphthalenes are readily prepared regioselectively under mild reaction conditions by the 6-endo-dig electrophilic cyclization of appropriate arene-containing propargylic alcohols by IC1, I 2, Br2, NBS, and PhSeBr. 3-Iodo-2-naphthols have also been prepared in excellent yields by the cyclization of analogous 1-aryl-3-alkyn-2-ones. This methodology readily accommodates various functional groups and has been successfully extended to the synthesis of substituted carbazoles and dibenzothiophenes.