874339-77-2

Basic information

• Product Name: (1S)-(4-{[5-tert-butoxycarbonylamino-1-(diethoxyphosphoryloxy-methyl)-pentyl]-isobutyl-sulfamoyl}-phenyl)-carbamic acid tert-butyl ester
• Synonyms: (1S)-(4-{[5-tert-butoxycarbonylamino-1-(diethoxyphosphoryloxy-methyl)-pentyl]-isobutyl-sulfamoyl}-phenyl)-carbamic acid tert-butyl ester
• CAS NO: 874339-77-2
• Molecular Weight: 679.813
• Mol File: 874339-77-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (1S)-(4-{[5-tert-butoxycarbonylamino-1-(diethoxyphosphoryloxy-methyl)-pentyl]-isobutyl-sulfamoyl}-phenyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-(4-{[5-tert-butoxycarbonylamino-1-(diethoxyphosphoryloxy-methyl)-pentyl]-isobutyl-sulfamoyl}-phenyl)-carbamic acid tert-butyl ester(874339-77-2)
• EPA Substance Registry System: (1S)-(4-{[5-tert-butoxycarbonylamino-1-(diethoxyphosphoryloxy-methyl)-pentyl]-isobutyl-sulfamoyl}-phenyl)-carbamic acid tert-butyl ester(874339-77-2)

Safety Data

• Hazardous Substances Data: 874339-77-2(Hazardous Substances Data)

Upstream product

• 900187-22-6 (1-S)-{4-[(5-tert-butoxycarbonylamino-1-hydroxymethyl-pentyl)-isobutyl-sulfamoyl]-phenyl}-carbamic acid tert-butyl ester 
• 78-40-0 triethyl phosphate 
• 814-49-3 diethyl chlorophosphate 

Downstream Products

• 874339-78-3 (2S)-phosphoric acid 6-amino-2-[(4-amino-benzenesulfonyl)-isobutyl-amino]-hexyl ester diethyl ester 

Relevant articles and documents

LYSINE-BASED PRODRUGS OF ASPARTYL PROTEASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION

The present invention provides processes for synthesizing lysine based compounds of the Formula (I); wherein R1 may be, for example, (HO)2P(O)-, (NaO)2P(O)-, wherein X may be, for example, NH2, Y may be H, F, Cl, or Br, and wherein n, X', Y', R2, R3, R4, R5 and R6 are as defined herein.

Lysine based compounds

The present invention provides lysine based compounds of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1 may be, for example, (HO)2P(O)—, (NaO)2P(O)—, alkyl-CO— or cycloalkyl-CO—, wherein X may be, for example, F, Cl, and Br, and wherein R2 and R3 are as defined herein.