87436-82-6Relevant academic research and scientific papers
STEREOCHEMICAL OBSERVATIONS ON THE WITTIG REACTION OF OXIDO PHOSPHONIUM YLIDES WITH ALDEHYDES
Maryanoff, Bruce E.,Reitz Allen B.,Duhl-Emswiler, Barbara A.
, p. 2477 - 2480 (2007/10/02)
The reaction of aldehydes with oxido ylides shows a dramatic dependence of alkene stereochemistry on the distance between oxygen and phosphorus atoms; ylides with proximal O and P atoms favor production of E alkenes.The high E stereoselectivity with γ-oxido ylides is not mainly attributable to intramolecular proton-exchange in a Wittig intermediate.
