874432-97-0

Upstream product

• 874397-88-3 (P(C₆H₅)2)2C₁₂H₈PtCl₂*CH₂Cl₂ 
• 55442-11-0 (R)-2,2'-bis(trifluoromethanesulfonylamino)-1,1'-binaphthyl 

Downstream Products

• 308084-79-9 (S)-(2,2'-bs(diphenylphosphanyl)biphenyl)dichloroplatinum(II) 

Relevant academic research and scientific papers

Enantiodiscrimination and enantiocontrol of neutral and cationic Pt II complexes bearing the Tropos biphep ligand: Application to asymmetric lewis acid catalysis

(Chemical Equation Presented) The stereochemically stable, enantiopure biphep-Pt complexes can be employed as an atropos asymmetric catalyst at 50°C or below. Both enantiomeric forms of this complex can be obtained by using either the chiral diamine (R)-dabn or its diamide (R)-dabnTf followed by chirally controlled formation of the single biphep-Pt enantiomer at higher (> 60°C) temperatures (see scheme; Tf=trifluoromethanesulfonate).

Diastereoisomer interconversion in chiral biphepPtX2 complexes

Reaction of biphepPt(COa) (biphep = 2,2'-bis(diphenylphosphino)-l,l/-biphenyl) with BINOL or HN(TCHPhCHPhOH (TfNO) yielded square-planar biphepPtX2 (X2 = BINOL, N(Tf)CHPhCHPhO) complexes as a mixture of diastereomers (-1:1). BiphepPtCk also reacted with Na2BINOL to generate biphepPt(BINOL) as a 1:1 mixture of diastereomers. With racemic BINOL or TfNO ligands, the mixtures were prone to isomerize to thermodynamic diastereomer mixtures (BINOL, 95:5; TfNO, +- 97:3) by an X2-X2 ligand-ligand exchange mechanism that was rapid at room temperature. With enantiopure ligands the X2-X2 ligandligand exchange process was degenerate and nonproductive. However, thermolysis of 1:1 mixtures of enantiopure biphepPt(BINOL) diastereomers (92-122 °C) cleanly established thermodynamic equilibrium by a process that involves biphenyl atropisomerism (AH= 27(2) kcal mol 1, AS= -5(5) eu). Two mechanisms for this process were considered, concerted stereoinversion via a planar seven-membered metallacycle, and one-arm-off prior to a biphenyl isomerization (anti disposed PPh2 units). In pyridine, a third mechanism for atropisomerism was identified and proposed to involve a five-coordinate pyridine intermediate (not observed) with an enhanced phosphine dissociation rate. Pyridine lowered the ; isomerization temperature of enantiopure complexes by -50 °C. X-ray structures of the thermodynamically favored biphepPt(TfNO) ((±)-4a) and the thermodynamically less favored biphepPt(BINOL) (A(S)-5b) diastereomers were obtained, and a stereochemical model to explain the diastereoselectivity was formulated.