874447-87-7 Usage
Molecular structure
The compound consists of a pyrrolidine ring, a carboxylic acid group, a chlorophenyl group, a methoxy group, a sulfonyl group, and various other functional groups.
Boc-protected derivative
The compound is a protected form of a chiral amino acid, which means it has a protecting group (boc) that prevents unwanted reactions from occurring during synthesis.
Chiral compound
The compound has a specific three-dimensional arrangement of atoms, which results in different stereoisomers (2S,4S).
Potential pharmaceutical application
The compound is used in pharmaceutical research and development due to its potential application in the synthesis of novel drugs and therapeutic agents.
Molecular weight
The molecular weight of the compound is 576.09 g/mol.
Solubility
The compound's solubility properties may vary depending on the solvent used, but it is generally soluble in organic solvents such as DMSO or methanol.
Stability
The compound is stable under normal environmental conditions, but it should be stored in a cool, dry place, and handled with proper safety precautions.
Synthesis
The compound can be synthesized through various chemical reactions, including the use of starting materials such as the parent amino acid, reagents, and catalysts.
Biological activity
The specific biological activity of the compound may vary depending on its target and mechanism of action, but it is generally being studied for its potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 874447-87-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,4,4 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 874447-87:
(8*8)+(7*7)+(6*4)+(5*4)+(4*4)+(3*7)+(2*8)+(1*7)=217
217 % 10 = 7
So 874447-87-7 is a valid CAS Registry Number.
874447-87-7Relevant academic research and scientific papers
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B
Collins, Ian,Caldwell, John,Fonseca, Tatiana,Donald, Alastair,Bavetsias, Vassilios,Hunter, Lisa-Jane K.,Garrett, Michelle D.,Rowlands, Martin G.,Aherne, G. Wynne,Davies, Thomas G.,Berdini, Valerio,Woodhead, Steven J.,Davis, Deborah,Seavers, Lisa C. A.,Wyatt, Paul G.,Workman, Paul,McDonald, Edward
, p. 1255 - 1273 (2007/10/03)
Structure-based drug design of novel isoquinoline-5-sulfonamide inhibitors of PKB as potential antitumour agents was investigated. Constrained pyrrolidine analogues that mimicked the bound conformation of linear prototypes were identified and investigated by co-crystal structure determinations with the related protein PKA. Detailed variation in the binding modes between inhibitors with similar overall conformations was observed. Potent PKB inhibitors from this series inhibited GSK3β phosphorylation in cellular assays, consistent with inhibition of PKB kinase activity in cells.
