87447-76-5Relevant academic research and scientific papers
Synthesis and evaluation of 5-aryl-3-(4-hydroxyphenyl)-1,3,4-oxadiazole-2- (3H)-thiones as P-glycoprotein inhibitors
Loetchutinat, Chatchanok,Chau, Francois,Mankhetkorn, Samlee
, p. 728 - 730 (2007/10/03)
5-Aryl-3-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thiones 3 were prepared by cyclocondensation of 1-(4-hydroxyphenyl)-2-aroylhydrazines with thiophosgene. All compounds exhibited antiproliferation activity in K562, IC50 ranging from 24 to 94 μM comparable efficacy with apigenin and genistein and showed more potent antiproliferation of K562/adr cells, highly expressing P-glycoprotein. Compounds 3g, 3e and 3a inhibited the function of P-glycoprotein with the α0.5 equal to 10±3 μM, 21±5 μM and 34±7 μM, respectively.
