874509-45-2

Basic information

• Product Name: 5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID
• Synonyms: 5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID;5-broMo-4-Methylthiazole-2-carboxylic acid
• CAS NO: 874509-45-2
• Molecular Formula: C5H4BrNO2S
• Molecular Weight: 222.06
• Mol File: 874509-45-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 376°C at 760 mmHg
• Flash Point: 181.2°C
• Appearance: /
• Density: 1.895
• Vapor Pressure: 2.55E-06mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID(874509-45-2)
• EPA Substance Registry System: 5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID(874509-45-2)

Safety Data

• Hazardous Substances Data: 874509-45-2(Hazardous Substances Data)

Usage

General Description

5-Bromo-4-methyl-2-thiazolecarboxylic acid is a chemical compound with the molecular formula C6H5BrNO2S. It is a derivative of thiazolecarboxylic acid and contains a bromine atom at the 5th position and a methyl group at the 4th position of the thiazole ring. 5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID is commonly used in the pharmaceutical and agricultural industries as a building block for the synthesis of various drugs and pesticides. It exhibits antimicrobial and antifungal properties, making it valuable in the development of new pharmaceuticals. Additionally, it has potential applications in the field of material science for the synthesis of functionalized polymers and materials.

InChI:InChI=1/C5H4BrNO2S/c1-2-3(6)10-4(7-2)5(8)9/h1H3,(H,8,9)

Upstream product

• 859481-85-9 5-bromo-4-methyl-thiazole-2-carbonitrile 
• 79247-78-2 2,5-dibromo-4-methylthiazole 
• 124-38-9 carbon dioxide 
• 859480-77-6 5-bromo-4-methyl-thiazole-2-carboxylic acid amide 

Downstream Products

• 79247-79-3 methyl 5-bromo-4-methylthiazole-2-carboxylate 

Relevant articles and documents

Viral polymerase inhibitors

An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I: wherein R1 is selected from: H, haloalkyl, (C1-6)alkyl, (C2-6)alkenyl, (C3-7)cycloalkyl, (C2-6)alkynyl, (C5-7)cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted; R2 is selected from (C1-6)alkyl, (C3-7)cycloalkyl, (C6-10)bicycloalkyl, 6- or 10-membered aryl, or Het all optionally substituted; B is N or CR5, wherein R5 is H, halogen, haloalkyl, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; X is N or CR5; D is N or CR5; each of Y1 and Y2 is independently O or S; Z is O, N, or NRz wherein Rz is H, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; R3 and R4 are each independently H, (C1-6)alkyl, first (C3-7)cycloalkyl or 6- or 10-membered aryl, Het (C1-6)alkyl-6- or 10-membered aryl, (C1-6)alkyl-Het; or each R3 and R4 are independently covalently bonded together to form second (C3-7)cycloalkyl, or heterocycle, all optionally substituted; or when Z is N, either R3 or R4 are independently covalently bonded thereto to form a nitrogen-containing heterocycle; R7 is H, (C1-6 alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; or R7 is covalently bonded to either of R3 or R4 to form a heterocycle; A is (C1-6) alkyl-CONHR8 wherein R8 is-6- or 10-membered aryl, or Het; or A is a 6- or 10-membered aryl, or Het said aryl or Het being optionally substituted; or a salt or a derivative thereof; such compounds being potent inhibitors of HCV NS5B polymerase.