87451-13-6Relevant academic research and scientific papers
β-Lactam Synthesis through Diodomethane Addition to Amide Dianions
Zidan, Alaa,Garrec, Julian,Cordier, Marie,El-Naggar, Abeer M.,Abd El-Sattar, Nour E. A.,Khalil, Ali,Hassan, Mohamed Ali,El Kaim, Laurent
, p. 12179 - 12183 (2017/09/06)
We present a novel route for the quick and easy synthesis of a broad range of β-lactams. The synthesis involves a [3+1] cyclization of amide dianions with diiodomethane. In contrast to the seminal work of Hirai et al. from 1979, the reaction proved to be
Carbonylative Ring Expansion of Aziridines to β-Lactams with Rhodium-Complexed Dendrimers on a Resin
Lu, Shui-Ming,Alper, Howard
, p. 3558 - 3561 (2007/10/03)
Rhodium-complexed dendrimers, supported on a resin, were evaluated as catalysts for the carbonylative ring expansion reactions of a variety of aziridines with carbon monoxide to give β-lactams. The effects of reaction temperature, solvent, time, and press
Enantiospecific and Stereospecific Rhodium(I)-Catalyzed Carbonylation and Ring Expansion of Aziridines. Asymmetric Synthesis of β-Lactams and the Kinetic Resolution of Aziridines
Calet, Serge,Urso, Fabio,Alper, Howard
, p. 931 - 934 (2007/10/02)
Rhodium(I) complexes catalyze the regiospecific ring expansion-carbonylation reaction of aziridines to β-lactams.This process is both stereospecific and enantiospecific, occuring with retention of configuration e.g., (S)-1-tert-butyl-2-phenylaziridine is
