6941-21-5

Basic information

• Product Name: N-tert-butyl-2-phenylacetamide
• Synonyms: benzeneacetamide, N-(1,1-dimethylethyl)-
• CAS NO: 6941-21-5
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.2695
• Mol File: 6941-21-5.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 349.4°C at 760 mmHg
• Flash Point: 208.6°C
• Density: 0.984g/cm³
• Vapor Pressure: 4.72E-05mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: N-tert-butyl-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butyl-2-phenylacetamide(6941-21-5)
• EPA Substance Registry System: N-tert-butyl-2-phenylacetamide(6941-21-5)

Safety Data

• Hazardous Substances Data: 6941-21-5(Hazardous Substances Data)

Upstream product

• 140-29-4 phenylacetonitrile 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 
• 27151-60-6 1-t-butyl-3-phenylaziridin-2-one 
• 1589-82-8 phenylmagnesium bromide 
• 1634-04-4 tert-butyl methyl ether 
• 65-85-0 benzoic acid 
• 541-16-2 t-butyl malonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 60-12-8 2-phenylethanol 
• 122-78-1 phenylacetaldehyde 
• 75-64-9 tert-butylamine 
• 536-74-3 phenylacetylene 
• 774-65-2 benzoic acid tert-butyl ester 

Downstream Products

• 103-81-1 Benzeneacetamide 
• 99-87-6 4-methylisopropylbenzene 
• 87451-13-6 (S)-1-tert-Butyl-3-phenylazetidin-2-one 
• 70161-03-4 tert-butyl-methyl-phenethyl-amine 
• 94430-23-6 2-tert-butoxy-N-tert-butyl-2-phenylethanamide 
• 5466-04-6 N-Isobutyryl-C-phenylglycin 
• 24070-10-8 2-methyl-N-phenethylpropan-2-amine 

Relevant articles and documents

A convenient synthesis of N-tert-butyl amides by the reaction of di-tert-butyl dicarbonate and nitriles catalyzed by Cu(OTf)2

The utility of Cu(OTf)2 as the catalyst for the synthesis of a series of N-tert-butyl amides in excellent isolated yields via the reaction of nitriles (alkyl, aryl, benzyl, and furyl nitriles) with di-tert-butyl dicarbonate is described. Cu(OTf)2 is a highly stable and efficient catalyst for the present Ritter reaction under solvent-free conditions at room temperature.

CoFe2O4?SiO2-NH-βCD-BF3 as a supramolecular nanocomposite: Synthesis, characterization and catalytic activity

This manuscript describes synthesis of BF3-functionlized β-cylcodextrine grafted magnetic CoFe2O4 nanaoparticles as a hybrid magnetic nano-composite (CoFe2O4?SiO2-NH-βCD-BF3). The CoFe2O4?SiO2-NH-βCD-BF3 was fabricated by grafting of 6-O-toluenesulfonyl cyclodextrin (6-Ts-βCD) to 3-aminopropyl triethoxysilane coated magnetic CoFe2O4?SiO2 nanoparticles followed by combination with BF3. The CoFe2O4?SiO2-NH-βCD-BF3was characterized by FT-IR, TGA, VSM and SEM techniques. The feasibility of using CoFe2O4?SiO2-NH-βCD-BF3 as a magnetically recoverable catalyst was confirmed in the modified-Ritter reaction. The result showed that this novel nano-composite could serve as an efficient nanoreactor bearing super-acidic sites formed by immobilized BF3 and reuse at least for 6 times without loss in activity.

Ruthenium-Catalyzed Oxidative Amidation of Alkynes to Amides

Complex CpRuCl(PPh3)2 catalyzes reactions of terminal alkynes with 4-picoline N-oxide and primary and secondary amines to afford the corresponding amides. The reactions occur in chlorinated solvent and aqueous medium, showing applications in peptide chemistry. Stoichiometric studies reveal that the true catalysts of the processes are the vinylidene cations [CpRu(=C=CHR)(PPh3)2]+ which are oxidized to the Ru(η2-CO)-ketenes by the N-oxide. Finally, nucleophilic additions of primary and secondary amines to the free ketenes yield the corresponding amides.