874519-00-3

Upstream product

• 64-17-5 ethanol 
• 855411-61-9 2-bromo-4,4,6-trichloro-3,5-dimethyl-cyclohexa-2,5-dienone 
• 38730-40-4 2-bromo-4-chloro-3,5-dimethylphenol 
• 88-04-0 4-Chloro-3,5-dimethylphenol 
• 133-53-9 2,4-dichloro-3,5-dimethylphenol 

Relevant academic research and scientific papers

Benzyne 1,2,4-Trisubstitution and Dearomative 1,2,4-Trifunctionalization

Both 1,2,4-trisubstitution and dearomative 1,2,4-trifunctionalization of benzyne have been accomplished from sulfoxides bearing a penta-2,4-dien-1-yl moiety. These cascade transformations proceed through a benzyne insertion into the S═O bond and an uncommon regiospecific anionic [4,5]-sigmatropic rearrangement, furnishing a C-O, C-S, and C-C bond on the C1-, C2-, and C4-position of a benzene ring, respectively. This study showcases new cascade benzyne reaction modes involving both distal C-H bond functionalization and dearomatization.