874595-64-9

Upstream product

• 141-97-9 ethyl acetoacetate 
• 213454-27-4 3-cyclopropylamino-but-2-enoic acid ethyl ester 
• 301173-79-5 ethyl 1-cyclopropyl-5-hydroxy-2-methylindole-3-carboxylate 
• 383402-59-3 5-acetoxy-1-cyclopropyl-2-methyl-1H-indole-3-carboxylic acid ethyl ester 

Downstream Products

• 945041-42-9 7-bromo-8-(3-chloropropoxy)-5-cyclopropyl-1-[(3-chloro-4-fluoro-phenyl)amino]-5H-pyridazino[4,5-b]indole 
• 952650-05-4 C₂H₂O₄*C₂₄H₂₄BrClFN₅O 
• 865234-99-7 C₂₅H₂₆BrF₃N₂O₃S 

Relevant academic research and scientific papers

Synthesis and Antiviral Activity of Substituted Ethyl-2-Aminomethyl-5-Hydroxy-1H-Indole-3-Carboxylic Acids and Their Derivatives

Novel substituted 5-hydroxy-2-aminomethyl-1H-indole-3-carboxylic acids and their derivatives were synthesized. The antiviral properties of these compounds were investigated in relation to bovine viral diarrhea virus (BVDV), hepatitis C virus (HCV), and influenza A/Aichi/2/69 (H3N2) virus. Of the compounds synthesized here, only the 5-hydroxy-2-(dimethylaminomethyl)-1-methyl-6-pyridin-3-yl- and 5-hydroxy-2-(dimethylaminomethyl)-1-methyl-6-fluoro-1H-indole-3-carboxylic acid ethyl ester hydrochlorides had significant activity against these viruses, these agents not only suppressing the replication of influenza A/Aichi/2/69 (H3N2) virus in cell cultures at micromolar concentrations, but also demonstrating high efficacy, greater than that of Arbidol, in a model of influenza pneumonia in mice infected with influenza A/Aichi/2/69 (H3N2) virus, when given at a dose of 25 mg/kg/day.

5-Hydroxyindole-3-Carboxylate Derivatives and Uses Thereof

The present invention relates to 5-hydroxy-indole-3-carboxylate derivatives of formula I, or racemic mixture or optical isomers or pharmaceutically acceptable salts and/or hydrates thereof, wherein: substituents R1, R2, Z, X and Y ar