87461-07-2

Upstream product

• 3634-89-7 N-(p-toluenesulfonyl)aziridine 
• 762-04-9 phosphonic acid diethyl ester 
• 6367-75-5 2-(tosylamino)ethyl p-toluenesulfonate 
• 2303-76-6 sodium diethyl phosphite 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 2041-14-7 (2-aminethyl)phosphonic acid 
• 87461-15-2 2-<<2-(2,5-Dichlorphenylsulfonylamino)ethyl>(4-methylphenylsulfonyl)amino>ethylphosphonsaeure-diethylester 
• 87461-16-3 6-(2,5-Dichlorphenylsulfonyl)-8-(2,5-dichlorphenylsulfonylamino)-3-(4-methylphenylsulfonyl)-3,6-diazaoctylphosphonsaeure-diethylester 
• 87461-17-4 6,9-Bis(2,5-dichlorphenylsulfonyl)-11-(2,5-dichlorphenylsulfonylamino)-3-(4-methylphenylsulfonyl)-3,6,9-triazaundecylphosphonsaeure-diethylester 

Relevant academic research and scientific papers

PREPARATION OF OPTICALLY ACTIVE 2-AMINOALKYLPHOSPHINIC AND PHOSPHONIC ACIDS

The reaction of sodium alkylphosphinates or sodium dialkylphosphonates with tosylamino tosylates of amino alcohols derived from 1-aminoalkylcarboxylic acids gives high yields of optically active 2-tosylaminoalkylphosphinic or phosphonic esters.

Reactions with Aziridines (Aziranes), 29. N-Acylated or N-Sulfonated Esters of 2-Aminoethylphosphonic Acid by Mean of Base Catalyzed Aminoethylation of Diesters of Phosphoric Acid with Activated Aziridines.

The sodium salts 2 of diesters of phosphoric acid 1 are amidoethylated at phosphorus with N-acylaziridines 3 or N-sulfonylaziridines 13 under proper reaction conditions at room temperature.In this manner a broad variation of N-acylated or N-sulfonated esters of 2-aminoethylphosphonic acids (5a-u, 15a-i) are obtained, mostly in good yields. 2-Methylated 2-aminoethylphosphonic esters are formed selectively in two cases by reaction of 2-methylated activated aziridines.