2041-14-7Relevant articles and documents
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Finkelstein
, p. 2398 (1946)
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A new simple route to N-substituted 2-aminoethylphosphonic acids
Fu, Xiangkai,Gong, Chengbin,Ma, Xuebing,Wen, Shuying
, p. 2659 - 2664 (2007/10/03)
2-Aminoethylphosphonic acid (AEPA) and its N-substituted compounds were prepared by one step reaction using 2-chloroethylphosphonic acid with ammonia and amines (H2NMe, HNMeMe, HNEtEt, H2NPr-n, H2NCH2ph,H2NCH2CH2NH2 and H2N(C=NH)NH2 in a dilute alkaline solution below 20 °C with simple work- up and easy purification. The reaction was accelerated by catalytic amount of potassium iodide. The yield for the reaction products were 35.6 to 48.6% for the KI absence and 78.2 to 88.0% for the KI presence.
BIOSYNTHESIS OF NATURAL PRODUCTS WITH A P-C BOND: INCORPORATION OF D-GLUCOSE INTO 2-AMINOETHYLPHOSPHONIC ACID IN TETRAHYMENA THERMOPHILA AND OF D-GLUCOSE AND L-METHIONINE INTO FOSFOMYCIN IN STREPTOMYCES FRADIAE
Hammerschmidt, Friedrich
, p. 111 - 114 (2007/10/02)
D-Glucose was fed to Tetrahymena thermophila and to Streptomyces fradiae producing 2-aminoethylphosphonic acid and fosfomycin, respectively.The labelled products isolated indicate that the phosphoenol pyruvate mutase catalyzes the stereospecific transfer of the phospho group of (Z)-phosphoenol pyruvate from oxygen to carbon from the si-face.The methyl group of L-methionine is transferred intact to a precursor for fosfomycin.
Borane Reduction of Dialkoxyphosphorylcarboxamides as a New Route to Aminoalkylphosphonic Acids
Wasielewski, Czeslaw,Dembkowski, Leszek,Topolski, Marek
, p. 52 - 53 (2007/10/02)
A new, simple method for the synthesis of aminoalkylphosphonic acids is based on the reduction of dialkoxyphosphorylcarboxamides with the borane-dimethyl sulfide complex.