874638-98-9

Basic information

• Product Name: Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- (9CI)
• Synonyms: Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- (9CI);N-(1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
• CAS NO: 874638-98-9
• Molecular Formula: C₁₇H₁₈FN₃O₅
• Molecular Weight: 363.3403232
• Mol File: 874638-98-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- (9CI)(874638-98-9)
• EPA Substance Registry System: Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- (9CI)(874638-98-9)

Safety Data

• Hazardous Substances Data: 874638-98-9(Hazardous Substances Data)

Usage

General Description

Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- (9CI) is a chemical compound that belongs to the class of nucleosides. It is a modified form of the nucleoside cytidine, with a benzoyl group attached to the nitrogen atom and fluorine and methyl groups attached to the 2' carbon. Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- (9CI) is also known as 2'-deoxy-2'-fluorocytidine, and it has shown potential as an anti-cancer agent in preclinical studies. It has been investigated for its ability to inhibit the growth of cancer cells by interfering with their DNA replication and repair mechanisms. Additionally, it may have applications in antiviral therapy due to its ability to inhibit viral replication.

Upstream product

• 817204-33-4 (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine 
• 65-85-0 benzoic acid 
• 26661-13-2 N⁴-Benzoylcytosine 
• 85743-99-3 N-(2-Trimethylsilanyloxy-pyrimidin-4-yl)-benzamide 
• 817204-32-3 (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate 
• 119411-03-9 N-[2-Oxo-1-((2R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-oxo-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1,2-dihydro-pyrimidin-4-yl]-benzamide 
• 93-97-0 benzoic acid anhydride 
• 65-46-3 CYTIDINE 

Downstream Products

• 817204-33-4 (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine 
• 1064684-44-1 sofosbuvir 
• 1190307-88-0 sofosbuvir 
• 863329-66-2 2'-deoxy-2'-fluoro-2'-methyluridine 

Relevant articles and documents

Discovery of Novel Nucleotide Prodrugs with Improved Potency Against HCV Variants Carrying NS5B S282T Mutation

Resistant HCV variants carrying NS5B S282T mutation confer reduced sensitivity to sofosbuvir, the sole marketed NS5B polymerase inhibitor. On the basis of the finding that 2′-α-F-2′-β-C-methylcytidine 5′-triphosphate (8) was more potent than sofosbuvir's

Method for preparing (2'R)-2'-deoxy-2-fluoro-2-methyluridine

The invention provides a method for preparing sofosbuvir intermediate (2'R)-2'-deoxy-2-fluoro-2-methyluridine (compound VII), which comprises the following steps: (1) enabling a compound I to react with lithium diisopropylamide in aprotic solvent serving as a reaction solvent, controlling the reaction temperature to 0-5 DEG C, and treating after the reaction is completed to obtain a compound X; and (2) enabling the compound X to react with an NaClO solution having a concentration of 6-10 percent in the existence of a phase transfer catalyst, keeping the reaction temperature to 20-30 DEG C, and treating after the reaction is completed, wherein the reaction solvent is the aprotic solvent. The method does not require column chromatography in post-treatment, has a yield reaching 8 percent, and is applicable to industrial production.

High-yield synthesis method of sofosbuvir and sofosbuvir prepared with method

The invention relates to a high-yield synthesis method of sofosbuvir and sofosbuvir prepared with the method. The method comprises steps as follows: (a) cytidine and benzoic anhydride are dissolved in a first organic solvent for a reaction; TIDPSCl2 is ad