874651-69-1

Basic information

• Product Name: 2-Propen-1-one, 1-(2-bromo-4-methylphenyl)-3-phenyl-, (2E)-
• CAS NO: 874651-69-1
• Molecular Formula: C16H13BrO
• Molecular Weight: 301.183
• Mol File: 874651-69-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(2-bromo-4-methylphenyl)-3-phenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(2-bromo-4-methylphenyl)-3-phenyl-, (2E)-(874651-69-1)
• EPA Substance Registry System: 2-Propen-1-one, 1-(2-bromo-4-methylphenyl)-3-phenyl-, (2E)-(874651-69-1)

Safety Data

• Hazardous Substances Data: 874651-69-1(Hazardous Substances Data)

Upstream product

• 103286-27-7 2-bromo-4-methylacetophenone 
• 100-52-7 benzaldehyde 

Downstream Products

• 349547-15-5 5-methyl-3-phenyl-1H-inden-1-one 
• 874651-70-4 (R)-5-methyl-3-phenyl-1H-inden-1-ol 

Relevant articles and documents

Asymmetric Hydroarylation of Enones via Nickel-Catalyzed 5- Endo-Trig Cyclization

A nickel-catalyzed reductive cyclization of enones affords a wide array of indanones in high enantiomeric induction. The reaction is featured with an unprecedented broad scope of substrates. The versatility of the new method is demonstrated in several short stereoselective syntheses of medically valuable (R)-tolterodine, parent and deuterated (+)-indatraline, and an antitumor natural product, (+)-multisianthol. In comparison, these compounds cannot be prepared satisfactorily via analogous processes catalyzed by palladium.

Novel process and intermediates

The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II): 1?wherein R1, Rs