874660-22-7

Upstream product

• 874660-17-0 3-hydroxy-4-(4-methoxy-benzyloxy)-hept-6-enoic acid tert-butyl ester 
• 2749-70-4 bis(benzyloxy)methane 
• 760181-72-4 (R)-2-(4-methoxybenzyloxy)pent-4-en-1-ol 
• 874660-40-9 (R)-2-(4-Methoxy-benzyloxy)-pent-4-enal 
• 17482-09-6 benzyl iodomethyl ether 
• 874660-21-6 (S)-4-Isopropyl-3-{2-[(1S,2R)-2-(4-methoxy-benzyloxy)-1-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one 
• 874660-43-2 [(1S,2R)-2-(4-Methoxy-benzyloxy)-1-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetic acid 
• 874660-20-5 (3S,4R)-4-(4-Methoxy-benzyloxy)-3-methyl-1-triisopropylsilanyloxy-hept-6-en-3-ol 
• 874660-42-1 (R)-4-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxy-hept-6-en-3-one 
• 874660-19-2 (R)-4-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxy-hept-6-en-3-ol 
• 874660-41-0 (R)-4-(4-Methoxy-benzyloxy)-hept-6-ene-1,3-diol 

Downstream Products

• 874660-46-5 (R)-5-Benzyloxy-4-[(1S,2R)-2-(4-methoxy-benzyloxy)-1-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-pent-1-en-3-ol 

Relevant academic research and scientific papers

Convergent, stereoselective synthesis of the GHIJ fragment of brevetoxin A

(Chemical Equation Presented) A stereoselective synthesis of the GHIJ fragment of brevetoxin A utilizing a convergent assembly strategy is described. Glycolate alkylation, ring-closing metathesis, and Hosomi-Sakurai reactions were central operations in the construction of the G ring and J ring subunits, which were united through a Horner-Wadsworth-Emmons coupling. Subsequent dehydrative cyclization produced an endocyclic enol ether that was further elaborated to the tetracyclic GHIJ fragment of brevetoxin A.