874662-40-5Relevant academic research and scientific papers
Asymmetric organocatalysis with novel chiral thiourea derivatives: Bifunctional catalysts for the Strecker and nitro-Michael reactions
Tsogoeva, Svetlana B.,Yalalov, Denis A.,Hateley, Martin J.,Weckbecker, Christoph,Huthmacher, Klaus
, p. 4995 - 5000 (2005)
Novel bifunctional organocatalysts bearing both a thiourea moiety and an imidazole group on a chiral scaffold were synthesized and applied to the Strecker synthesis and nitro-Michael reaction. The addition of acetone to nitroolefins in the presence of these novel bifunctional organocatalysts gave enantioselectivities (up to 87 % ee) that are superior to those generated by the proline and/or homo-proline tetrazole catalysts described in the literature. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
