874676-85-4

Upstream product

• 910480-67-0 methyl 4-cyclohexylamino-3-iodobenzoate 
• 6224-91-5 trimethyl(prop-1-ynyl)silane 
• 19718-49-1 4-amino-3-iodobenzoic acid methyl ester 
• 108-94-1 cyclohexanone 

Downstream Products

• 874676-86-5 methyl 1-cyclohexyl-2-bromo-3-methyl-5-indolecarboxylate 
• 910480-73-8 1-cyclohexyl-2-(3-furyl)-3-methyl-5-indolecarboxylic acid methyl ester 
• 910480-74-9 1-cyclohexyl-3-methyl-2-phenyl-5-indolecarboxylic acid methyl ester 
• 910480-77-2 1-cyclohexyl-3-methyl-2-(2-pyridyl)-5-indolecarboxylic acid methyl ester 

Relevant academic research and scientific papers

VIRAL POLYMERASE INHIBITORS

The present invention relates to compounds represented by formula (I) wherein A, B, D, E, R2, R3, R4, R5, R6, R9, a, b, d and e are as defined herein, their salt or ester and pharmaceutical compositions thereof useful in the treatment of hepatitis C viral (HCV) infection. Said compounds were found to have inhibitory activity against HCV polymerase, especially as inhibitors of HCV NS5B polymerase

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds

Benzimidazole-based allosteric inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified to a variety of topologically related scaffolds. Replacement of the polar benzimidazole core by lipophilic indoles led to inhibitors with improved potency in the cell-based subgenomic HCV replicon system. Transposing the indole scaffold into a previously described series of benzimidazole-tryptophan amides generated the most potent inhibitors of HCV RNA replication in cell culture reported to date in this series (EC50 ～ 50 nM).

VIRAL POLYMERASE INHIBITORS

A compound, represented by formula (I) or an enantiomer, diastereoisomer or tautomer thereof : wherein either A or B is nitrogen and the other B or A is C, and the radicals R1, R2, R3, R5, R6, R7, R9, and R10 are as defined herein, or a salt, ester or derivative thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particulary those viral polymerases within the Flaviviridae family, more particulary to HCV polymerase.