87480-00-0

Usage

General Description

1,25-dihydroxy-23-thiavitamin D3, also known as 1,25(OH)2-23-thiaD3, is a synthetic analogue of the active form of vitamin D. It has been developed as a potential therapeutic agent for treating disorders related to vitamin D deficiency, such as osteoporosis and chronic kidney disease. 1,25-dihydroxy-23-thiavitamin D3 has been found to exhibit potent effects on calcium and phosphate metabolism, as well as bone formation and resorption. Additionally, 1,25-dihydroxy-23-thiavitamin D3 has shown promising anti-inflammatory and immunomodulatory properties, suggesting its potential for use in treating autoimmune and inflammatory diseases. Research on this novel vitamin D analogue continues to explore its therapeutic potential and safety profile for various medical conditions.

InChI:InChI=1/C26H42O3S/c1-17(15-30-16-25(3,4)29)22-10-11-23-19(7-6-12-26(22,23)5)8-9-20-13-21(27)14-24(28)18(20)2/h8-9,17,21-24,27-29H,2,6-7,10-16H2,1,3-5H3/b19-8+,20-9+/t17?,21-,22?,23+,24+,26-/m1/s1

Upstream product

• 66875-19-2 (20S)-20-Methyl-21-(tetrahydro-2H-pyran-2-yl)oxy-5-pregnen-1α,3β-diol 
• 81481-22-3 (20S)-20-methyl-5,16-pregnadien-1α,3β,21-triol 1,3-diacetate 
• 66875-21-6 (20S)-(20-Methyl-5-pregnen-1α,3β,21-triol)-1α,3β-diacetat 
• 77308-29-3 (17Z)-5,17-pregnadiene-1α,3β-diol diacetate 
• 140221-98-3 (20S)-20-methyl-1α,3β-bis(tert-butyldimethylsilyloxy)-21-(tetrahydropyran-2-yl)oxy-5-pregnene 
• 140222-04-4 1α,3β-bis(tert-butyldimethylsilyloxy)-23-thia-5,7-cholestadien-25-ol 
• 140222-01-1 (20S)-20-methyl-1α,3β-bis(tert-butyldimethylsilyloxy)-5,7-pregnadien-21-ol acetate 
• 66875-20-5 (20S)-(20-Methyl-21-(tetrahydro-2H-pyran-2-yl)oxy-5-pregnen-1α,3β-diol)-diacetat 
• 140222-00-0 (20S)-20-methyl-1α,3β-bis(tert-butyldimethylsilyloxy)-5-pregnen-21-ol acetate 
• 126771-88-8 1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol 
• 140221-99-4 1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5-en-22-ol 
• 139137-33-0 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propylsulfanyl)-2-methyl-propan-2-ol 
• 140222-03-3 Methanesulfonic acid (S)-2-[(1S,3R,9S,10R,13R,14R,17R)-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propyl ester 

Relevant academic research and scientific papers

Synthetic studies of vitamin D analogues. IX. Synthesis and differentiation-inducing activity of 1α,25-dihydroxy-23-oxa-, thia-, and azavitamin D3

Three vitamin D3 analogues, 1α,25-dihydroxy-23-oxavitamin D3 (3), 1α,25-dihydroxy-23-thiavitamin D3 (4) and 1α,25-dihydroxy-23-azavitamin D3 (5) were synthesized. In the differentiation-inducing activity of huma