140221-99-4

Upstream product

• 20998-18-9 1α,3β-dihydroxy-androst-5-en-17-one 

Downstream Products

• 139137-33-0 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propylsulfanyl)-2-methyl-propan-2-ol 
• 137939-47-0 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol 
• 140387-52-6 23-oxa-1α,25-dihydroxyvitamin D₃ 
• 87407-70-3 1α,25-dihydroxy-23-azavitamin D3 
• 87480-00-0 23-thia-1α,25-dihydroxyvitamin D₃ 
• 126771-94-6 Toluene-4-sulfonic acid (S)-2-[(1S,3R,9S,10R,13R,14R,17R)-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propyl ester 
• 72696-49-2 24F₂-1,25(OH)2-D₃ 
• 157769-84-1 (24R)-23-aza-1α,3β-bis[(tert-butyldimethylsilyl)oxy]-22-oxo-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)-6-ergosten-25-ol 
• 157769-85-2 C₃₅H₄₈N₄O₆ 

Relevant academic research and scientific papers

An alternative and efficient synthesis of 24,24-difluoro-1α,25-dihydroxyvitamin D3

An alternative synthesis of the title compound 2, a highly potent analog of 1α,25-dihydroxyvitamin D3 (1), is described. Starting with 1α,3β-bis[(tert-butyldimethylsilyl)oxy]androst-5-ene (8), 2 was obtained in 3.8% total yield through 10 steps. This method provides compound 2 in much higher yield than that reported previously.