87480-72-6Relevant academic research and scientific papers
Sila-Pharmaca, 36. - Sila-Procyclidine: A New Synthesis as well as Investigations of the Peripheral and Central Anticholinergic Activity
Tacke, Reinhold,Pikies, Jerzy,Linoh, Haryanto,Rohr-Aehle, Regine,Goenne, Sigrid
, p. 51 - 58 (2007/10/02)
Starting with Cl3SiCH2Cl, sila-procyclidine (1b) as well as its derivatives 2b (sila-trihexyphenidyl), 3b, and 4b (sila-cycrimine) were prepared by a new six-step synthesis with a total yields of 16 (1b), 19 (2b), 8 (3b) and 7percent (4b), respectively. -
Sila-Pharmaca, 37. - Preparation and Properties of the Enantiomers of the Antimuscarinic Agents Sila-Procyclidine and Sila-Tricyclamol Iodide: Optically Active Silanols with Silicon as the Centre of Chirality
Tacke, Reinhold,Linoh, Haryanto,Ernst, Ludger,Moser, Ulrich,Mutschler, Ernst,et al.
, p. 1229 - 1238 (2007/10/02)
The enantiomers of sila-procyclidine (R)-1b and (S)-1b 97percent ee (NMR), 99.7percent ee (DSC)> were obtained by resolution with L-(+)- and D-(-)-tartaric acid, respectively.Starting from (R)-1b and (S)-1b, the hydrochlorides (R)-2b and (S)-2b were pre
