874814-70-7Relevant articles and documents
Preparation method of 2-fluoro-6-(trifluoromethyl)benzene-1-sulfonyl chloride
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Paragraph 0012; 0027-0028; 0032-0033; 0037-0038; 0042-0048, (2017/08/28)
The invention belongs to the technical field of preparation of pesticide intermediates, and particularly relates to a preparation method of 2-fluoro-6-(trifluoromethyl)benzene-1-sulfonyl chloride. The preparation method comprises steps as follows: firstly, 2-chloro-6-(trifluoromethyl)benzene-1-sulfonyl chloride is prepared from 2-chloro-6-trifluoromethyl phenylamine as a raw material, and 2-fluoro-6-(trifluoromethyl)benzene-1-sulfonyl chloride is prepared through a substitution reaction. The raw materials are inexpensive and available, a synthetic route is novel, the fluoro yield is high, the total yield is 80% or higher, the purity can reach 98% or higher, and the preparation method is suitable for industrial production.