433-94-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-3-chlorobenzotrifluoride is used as a molecular determinant for the selective inhibition of cyclooxygenase-2 (COX-2) by lumiracoxib. This application is significant because COX-2 inhibition is a common target for anti-inflammatory and pain relief medications, making 2-Amino-3-chlorobenzotrifluoride a valuable component in the development of such drugs.
Additionally, due to its unique chemical structure, 2-Amino-3-chlorobenzotrifluoride may have potential applications in other areas of the pharmaceutical industry, such as the synthesis of other drug candidates or as a building block for more complex molecules with specific biological activities.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Amino-3-chlorobenzotrifluoride can be utilized as a starting material or intermediate for the production of various organic compounds. Its reactive functional groups allow for further modification and incorporation into more complex molecules, making it a valuable asset in the synthesis of specialty chemicals, agrochemicals, and other industrial products.
Used in Material Science:
The unique combination of chlorine, amino, and trifluoromethyl groups in 2-Amino-3-chlorobenzotrifluoride may also make it a candidate for the development of new materials with specific properties. For example, it could be used in the design of novel polymers, coatings, or adhesives with enhanced performance characteristics, such as improved thermal stability, chemical resistance, or adhesion properties.

InChI:InChI=1/C7H5ClF3N/c8-5-3-1-2-4(6(5)12)7(9,10)11/h1-3H,12H2

Upstream product

• 361-17-1 N-(2-chloro-6-trifluoromethyl-phenyl)-phthalimide 
• 75-63-8 Bromotrifluoromethane 
• 106-47-8 4-chloro-aniline 
• 95-51-2 o-chloroaniline 
• 19348-45-9 N-(2-chloro-6-methyl-phenyl)-phthalimide 
• 124421-17-6 2-(trichloromethyl)-6-chlorophenyl phthalimide 
• 2314-97-8 iodotrifluoromethane 
• 83753-56-4 pyridine-2-carboxylic acid N-(2-chlorophenyl)amide 
• 87-63-8 2-chloro-6-methylaniline 

Downstream Products

• 124421-02-9 1-(2-Chloro-6-trifluoromethyl-phenyl)-3-pyridin-4-yl-urea 
• 870703-71-2 4-bromo-2-chloro-6-(trifluoromethyl)aniline 
• 874814-70-7 2-chloro-6-trifluoromethylbenzenesulfonyl chloride 
• 1207315-84-1 2-chloro-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)aniline 
• 2965-99-3 C₁₄H₈Cl₂F₃NO₂ 
• 1393843-21-4 2-(2-chloro-6-fluorophenyl)-N-[2-chloro-6-(trifluoromethyl)phenyl]-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole-7-carboxamide 
• 871326-61-3 (2-chloro-6-trifluoromethyl-phenyl)-thiourea 
• 141474-47-7 N-(2-chloro-6-(trifluoromethyl)phenyl)acetamide 

Relevant academic research and scientific papers

Coordinating Activation Strategy-Induced Selective C?H Trifluoromethylation of Anilines

A simple protocol for the synthesis of 2-(trifluoromethyl)aniline derivatives through a coordinating activation strategy was developed. The reaction showed good reactivity and gave the target products in moderate to good yields. Pleasingly, the directing group could be recovered in excellent yield. Furthermore, this strategy allowed efficient access to the synthesis of floctafenine. A single-electron-transfer mechanism was proposed to be responsible for this trifluoromethylation reaction.

Trifluoromethylation of various aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide

Trifluoromethylation of aromatic and hetero-aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide was investigated. Various trifluoromethylated benzene derivatives, six-membered nitrogen-containing aromatic compounds and five-membered hetero-aromatic compounds were obtained under mild conditions. General orientation of electrophilic substitution of aromatic compounds was observed similarly as reported in other radical trifluoromethylation previously.

N-phenyl-N'-pyridinylureas as anticonvulsant agents

A series of N-phenyl-N'-pyridinylureas was examined for anticonvulsant activity. Extensive structure/activity investigations revealed optimal activity in the N-(2,6-disubstituted-phenyl)-N'-(4-pyridinyl)urea series, with 37 exhibiting the best overall anticonvulsant profile. Compound 37 was effective against seizures induced by maximal electroshock but did not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The overall pharmacological profile suggests that 37 would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures. Compound 37 was selected for Phase 1 clinical trials.

Reactions of Trifluoromethyl Bromide and Related Halides: Part 10. Perfluoroalkylation of Aromatic Compounds induced by Sulphur Dioxide Radical Anion Precursors

Perfluoroalkylation of electron-rich aromatic compounds with trifluoromethyl bromide, or long-chain perfluoroalkyl iodides, was performed in the presence of sodium dithionite or zinc-sulphur dioxide.This alkylation occurred at the ortho and para positions relative to the amino or hydroxy substitutent.Pyrroles were perfluoroalkylated regioselectively at the 2-position.This alkylation was interpreted as a radical aromatic substitution; the formation of the perfluoroalkyl radical can be induced by a single-electron transfer from sulphur dioxide radical anion to the perfluoroalkyl halide.

Perfluoroalkylation of Anilines in the Presence of Zinc and Sulphur Dioxide

Arylamines are transformed into their ortho- and para-trifluoromethyl derivatives by the action of trifluoromethyl bromide under slight pressure in the presence of 0.15 equiv. of zinc and sulphur dioxide in dimethylformamide.

Preparation of 2-amino-5-halobenzotrifluoride

2-Amino-5-halobenzotrifluorides are prepared to the virtual exclusion of other monohalogenated isomers by halogenating an aminobenzotrifluoride with a hydrohalide acid in the presence of selected oxidants.