874823-38-8Relevant academic research and scientific papers
Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new mer kinase inhibitors
Zhang, Weihe,Zhang, Dehui,Stashko, Michael A.,DeRyckere, Deborah,Hunter, Debra,Kireev, Dmitri,Miley, Michael J.,Cummings, Christopher,Lee, Minjung,Norris-Drouin, Jacqueline,Stewart, Wendy M.,Sather, Susan,Zhou, Yingqiu,Kirkpatrick, Gregory,Machius, Mischa,Janzen, William P.,Earp, H. Shelton,Graham, Douglas K.,Frye, Stephen V.,Wang, Xiaodong
, p. 9683 - 9692 (2013)
Abnormal activation or overexpression of Mer receptor tyrosine kinase has been implicated in survival signaling and chemoresistance in many human cancers. Consequently, Mer is a promising novel cancer therapeutic target. A structure-based drug design appr
