874893-89-7Relevant academic research and scientific papers
Transition-metal-free hydration of nitriles using potassium tert -butoxide under anhydrous conditions
Midya, Ganesh Chandra,Kapat, Ajoy,Maiti, Subhadip,Dash, Jyotirmayee
, p. 4148 - 4151 (2015)
Potassium tert-butoxide acts as a nucleophilic oxygen source during the hydration of nitriles to give the corresponding amides under anhydrous conditions. The reaction proceeds smoothly for a broad range of substrates under mild conditions, providing an efficient and economically affordable synthetic route to the amides in excellent yields. This protocol does not need any transition-metal catalyst or any special experimental setup and is easily scalable to bulk scale synthesis. A single-electron-transfer radical mechanism as well as an ionic mechanism have been proposed for the hydration process.
Pd-catalyzed amidation of 2-chloro- and 2,7-dichloro-1,8-naphthyridines
Ligthart,Ohkawa, Haruki,Sijbesma, Rint P.,Meijer
, p. 375 - 378 (2007/10/03)
The catalytic amidation between 2-chloro- and 2,7-dichloro-1,8- naphthyridines and primary amides bearing functional groups is reported. When Pd(OAc)2, xantphos, and K2CO3 are used, it is possible to obtain symmetric as we
