874903-80-7Relevant academic research and scientific papers
Orally active purine-based inhibitors of the heat shock protein 90
Biamonte, Marco A.,Shi, Jiandong,Hong, Kevin,Hurst, David C.,Zhang, Lin,Fan, Junhua,Busch, David J.,Karjian, Patricia L.,Maldonado, Angelica A.,Sensintaffar, John L.,Yang, Yong-Ching,Kamal, Adeela,Lough, Rachel E.,Lundgren, Karen,Burrows, Francis J.,Timony, Gregg A.,Boehm, Marcus F.,Kasibhatla, Srinivas R.
, p. 817 - 828 (2007/10/03)
Orally active Hsp90 inhibitors are of interest as potential chemotherapeutic agents. Recently, fully synthetic 8-benzyladenines and 8-sulfanyladenines such as 4 were disclosed as Hsp90 inhibitors, but these compounds are not water soluble and consequently
