874907-09-2

Upstream product

• 63082-55-3 diethyl (E)-cinnamyl malonate 
• 17714-42-0 1,3-dibromo-1-phenylpropane 
• 105-53-3 diethyl malonate 
• 26395-09-5 diethyl 2-(3-phenylpropyl)malonate 

Downstream Products

• 874907-15-0 (1R,2S)-1-tert-Butoxycarbonylamino-2-phenyl-cyclobutanecarboxylic acid ethyl ester 
• 874907-14-9 (1S,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclobutanecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of Functionalized Tetrahydropyridines by SnCl4-Mediated [4+2] Cycloaddition between Donor–Acceptor Cyclobutanes and Nitriles

Cycloadditions of strained carbocycles promoted by Lewis acids are powerful methods to construct heterocyclic frameworks. In fact, the formal [3+2] cycloadditions of donor–acceptor (DA) cyclopropanes with nitriles has seen particular success in synthesis. In this work, we report on the first [4+2] cycloaddition of nitriles with DA cyclobutanes by Lewis acid activation. Tetrahydropyridine derivatives were obtained in up to 91 % yield from various aryl-activated cyclobutane diesters and aliphatic or aromatic nitriles.

Synthesis of the four stereoisomers of cyclobutane analogues of phenylalanine in enantiomerically pure form

All stereoisomers of 1-amino-2-phenylcyclobutanecarboxylic acid-c 4Phe-have been synthesized and the series cnPhe has thus been completed. The use of two different strategies based on a cyclization reaction, starting from ethyl isocy