87491-79-0

Basic information

• Product Name: 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE
• Synonyms: 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE;1-[(chloroMethyl)sulfonyl]naphathalene
• CAS NO: 87491-79-0
• Molecular Formula: C₁₁H₉ClO₂S
• Molecular Weight: 240.7
• Product Categories: API intermediates
• Mol File: 87491-79-0.mol

Chemical Properties

• Boiling Point: 441.564 °C at 760 mmHg
• Flash Point: 220.85 °C
• Appearance: /
• Density: 1.362 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE(87491-79-0)
• EPA Substance Registry System: 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE(87491-79-0)

Safety Data

• Hazardous Substances Data: 87491-79-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its reactivity with nucleophiles allows for the creation of diverse chemical structures, contributing to the discovery and production of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE serves as a key component in the synthesis of agrochemicals. Its ability to react with nucleophiles facilitates the production of effective pesticides and other agricultural chemicals that protect crops and enhance yield.
Used in Fine Chemicals Industry:
1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE is utilized as a building block in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, dyes, and specialty chemicals. Its versatility in organic synthesis contributes to the development of high-quality and specialized products.
It is crucial to handle 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE with care due to the potential reactivity and hazards associated with the chloromethylsulfonyl group. Proper safety measures should be implemented to ensure safe usage in industrial applications.

InChI:InChI=1/C11H9ClO2S/c12-8-15(13,14)11-7-3-5-9-4-1-2-6-10(9)11/h1-7H,8H2

Upstream product

• 74-97-5 chlorobromomethane 
• 85-46-1 1-Naphthalenesulfonyl chloride 

Downstream Products

• 925450-69-7 1-[2-(2-Chloroethoxy)-6-nitrophenylmethanesulfonyl]naphthalene 
• 925450-77-7 3-(naphthalene-1-sulfonylmethyl)-4-nitrobenzoic acid methyl ester 
• 925450-58-4 1-[3-(3-chloro-propoxy)-2-nitro-phenyl-methanesulfonyl]-naphthalene 
• 925450-82-4 2-[3-(naphthalen-1-ylsulfonylmethyl)-4-nitrophenyl][1,3]dioxolane 
• 1253422-90-0 C₂₂H₂₂ClN₃O₄S 
• 1086838-51-8 (R)-t-butyl 1-{[3-(naphth-1-ylsulfonyl)methyl]-4-nitrophenyl}pyrrolidin-3-ylcarbamate 
• 1232361-11-3 C₂₆H₂₉N₃O₆S 
• 1199795-12-4 1-methyl-4-{4-nitro-3-[(1-naphthalenesulfonyl)methyl]phenyl}piperazine 
• 1086838-55-2 t-butyl 1-{3-[(naphth-1-ylsulfonyl)methyl]-4-nitrophenyl}-piperidin-4-ylcarbamate 
• 952501-26-7 1-[3-(2-Chloro-1-chloromethyl-ethoxy)-2-nitro-phenylmethane-sulfonyl]-naphthalene 
• 928782-47-2 1-Benzyl-3-[3-(1-Naphthylsulfonylmethyl)-4-nitrophenoxy]-piperidine 
• 928782-38-1 1-Benzyl-4-[3-(1-naphthylsulfonylmethyl)-4-nitrophenoxy]piperidine 
• 928782-34-7 1-benzyl-3-[3-(naphthalene-1-sulfonylmethyl)-4-nitro-phenoxy]-pyrrolidine 
• 928782-43-8 4-[3-(1-Naphthylsulfonylmethyl)-4-nitrophenoxymethyl]piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Chloromethyl sulfones from sulfonyl chlorides via a one-pot procedure

A simplified one-pot transformation of a diverse set of aryl- and heteroaryl-sulfonyl chlorides into the corresponding chloromethyl sulfones is described.

5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists

Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT 6 receptor ligands with improved pharmacokinetic and pharmacological properties. One selected example, 18b, showed good brain penetrability and a generally favorable pharmacokinetic profile with procognitive efficacy in the rat novel object recognition assay. The synthesis and structure-activity relationship of this potent class are discussed.

AMINOAZACYCLYL-3-SULFONYLINDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS

The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.

Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

Azinyl-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.