925450-77-7Relevant academic research and scientific papers
Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists
Liu, Kevin G.,Robichaud, Albert J.,Greenfield, Alexander A.,Lo, Jennifer R.,Grosanu, Cristina,Mattes, James F.,Cai, Yanxuan,Zhang, Guo Ming,Zhang, Jean Y.,Kowal, Dianne M.,Smith, Deborah L.,Di, Li,Kerns, Edward H.,Schechter, Lee E.,Comery, Thomas A.
experimental part, p. 650 - 662 (2011/02/28)
As part of our efforts to develop agents for cognitive enhancement, we have been focused on the 5-HT6 receptor in order to identify potent and selective ligands for this purpose. Herein we report the identification of a novel series of 3-sulfonylindazole derivatives with acyclic amino side chains as potent and selective 5-HT6 antagonists. The synthesis and detailed SAR of this class of compounds are reported.
Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands
-
Page/Page column 75, (2010/11/25)
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
