874915-60-3Relevant academic research and scientific papers
Acid promoted cyclodehydration of amino alcohols with amide acetal
Hwang, Soonho,Park, Heemin,Kwon, Yongseok,Kim, Sanghee
, p. 60017 - 60024 (2015/02/19)
A convenient acid-promoted cyclization protocol for the formation of azaheterocycles from amino alcohols is described. The reaction involves the use of N,N-dimethylacetamide dimethyl acetal (DMADA) as the activating reagent of the hydroxyl group. Using this protocol, pyrrolidines or piperidines with various substituents can be synthesized in good to high yields.
Intramolecular additions of various π-nucleophiles to chemoselectively activated amides and application to the synthesis of (±)-tashiromine
Belanger, Guillaume,Larouche-Gauthier, Robin,Menard, Frederic,Nantel, Miguel,Barabe, Francis
, p. 704 - 712 (2007/10/03)
Vilsmeier-Haack type cyclizations proved to be particularly efficient for generating parts of the polycyclic cores of many alkaloids, although only monocyclizations have so far been reported. With the goal of rapidly and efficiently constructing polycycli
