387337-32-8Relevant academic research and scientific papers
Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent
Lawson, Edward C.,Santulli, Rosemary J.,Dyatkin, Alexey B.,Ballentine, Scott A.,Abraham, William M.,Rudman, Sandra,Page, Clive P.,de Garavilla, Lawrence,Damiano, Bruce P.,Kinney, William A.,Maryanoff, Bruce E.
, p. 4208 - 4216 (2007/10/03)
The α4β1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent α4β1 antagonists that we evaluated for
