874961-93-0Relevant articles and documents
Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators
Ray, Nicholas C.,Clark, Robin D.,Clark, David E.,Williams, Karen,Hickin,Crackett, Peter H.,Dyke, Hazel J.,Lockey, Peter M.,Wong, Melanie,Devos, Rene,White, Anne,Belanoff, Joseph K.
, p. 4901 - 4905 (2008/12/22)
A virtual screening approach comprising a 3-D similarity search based on known GR modulators was used to identify a novel series of non-steroidal glucocorticoid receptor (GR) antagonists. Optimization of the initial hit to provide potent compounds which e
