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874975-32-3

874975-32-3

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874975-32-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 874975-32-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,9,7 and 5 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 874975-32:
(8*8)+(7*7)+(6*4)+(5*9)+(4*7)+(3*5)+(2*3)+(1*2)=233
233 % 10 = 3
So 874975-32-3 is a valid CAS Registry Number.

874975-32-3Upstream product

874975-32-3Downstream Products

874975-32-3Relevant articles and documents

Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac myosin

Morgan, Bradley P.,Muci, Alexander,Lu, Pu-Ping,Qian, Xiangping,Tochimoto, Todd,Smith, Whitney W.,Garard, Marc,Kraynack, Erica,Collibee, Scott,Suehiro, Ion,Tomasi, Adam,Valdez, S. Corey,Wang, Wenyue,Jiang, Hong,Hartman, James,Rodriguez, Hector M.,Kawas, Raja,Sylvester, Sheila,Elias, Kathleen A.,Godinez, Guillermo,Lee, Kenneth,Anderson, Robert,Sueoka, Sandra,Xu, Donghong,Wang, Zhengping,Djordjevic, Nebojsa,Malik, Fady I.,Morgans, David J.

, p. 472 - 477 (2010)

We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit compound (1), potent, selective, and soluble myosin activators were designed culminating in the discovery of omecamtiv mecarbil (24). Compound 24 is currently in clinical trials for the treatment of systolic heart failure.

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