874975-33-4Relevant academic research and scientific papers
Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac myosin
Morgan, Bradley P.,Muci, Alexander,Lu, Pu-Ping,Qian, Xiangping,Tochimoto, Todd,Smith, Whitney W.,Garard, Marc,Kraynack, Erica,Collibee, Scott,Suehiro, Ion,Tomasi, Adam,Valdez, S. Corey,Wang, Wenyue,Jiang, Hong,Hartman, James,Rodriguez, Hector M.,Kawas, Raja,Sylvester, Sheila,Elias, Kathleen A.,Godinez, Guillermo,Lee, Kenneth,Anderson, Robert,Sueoka, Sandra,Xu, Donghong,Wang, Zhengping,Djordjevic, Nebojsa,Malik, Fady I.,Morgans, David J.
, p. 472 - 477 (2011/03/20)
We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit compound (1), potent, selective, and soluble myosin activators were designed culminating in the discovery of omecamtiv mecarbil (24). Compound 24 is currently in clinical trials for the treatment of systolic heart failure.
Syntheses of ureas
-
Page/Page column 19, (2010/02/15)
The present invention provides intermediates, synthetic methods and novel urea compositions of matter.
