874979-47-2Relevant academic research and scientific papers
2-(1,3-Dioxan-2-yl)ethylsulfonyl group: A new versatile protecting and activating group for amine synthesis
Sakamoto, Izumi,Izumi, Norimasa,Yamada, Taeko,Tsunoda, Tetsuto
, p. 71 - 74 (2006)
(Chemical Equation Presented) 2-(1,3-Dioxan-2-yl)ethylsulfonyl (Dios) chloride was synthesized and used as a new versatile sulfonating agent for amines. Primary and secondary amines were sulfonated very easily in excellent yields with Dios chloride. N-Nonsubstituted and N-monosubstituted Dios-amides, activated amines, were alkylated satisfactorily under new Mitsunobu conditions utilizing (cyanomethylene)tributylphosphorane (CMBP). The Dios group is very stable under basic and reductive conditions and is removed by heating in a hot aqueous solution of trifluoroacetic acid.
