874988-47-3

Upstream product

• 116557-81-4 1-benzyl-4-(4-methoxy)phenyl-1H-1,2,3-triazole 
• 106-43-4 para-chlorotoluene 
• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
• 24785-38-4 1-methoxy-4-[2-(4-methylphenyl)ethynyl]benzene 
• 622-79-7 benzyl azide 

Relevant academic research and scientific papers

Pd-catalyzed ligand-free C(5)–H arylation of 1,4-disubstituted 1,2,3-triazoles promoted by microwaves

Pd(OAc)2-catalyzed regioselective C(5)–H arylation of 1,4-disubstituted 1,2,3-triazoles was achieved without ligand under microwave conditions in 1 h, generating 1,4,5-trisubstituted 1,2,3-triazoles with good to excellent yields. The obtained molecules can be easily converted into 4,5-disubstituted 1,2,3-triazoles through the debenzylation process with one-pot manipulation.

Palladium-catalyzed direct arylations of 1,2,3-triazoles with aryl chlorides using conventional heating

Generally applicable, palladium-catalyzed direct arylations of 1,2,3-triazoles with aryl chlorides were accomplished through conventional heating at reaction temperatures of 105-120°C. Thereby, intra- and intermolecular C-H bond functionalizations were achieved with a variety of differently substituted chlorides as electrophiles, bearing numerous valuable functional groups.

Synthesis and biological evaluation of cis-combretastatin analogs and their novel 1,2,3-triazole derivatives

Three cis-combretastatin analogs (8-10) and three novel 1,2,3-triazole derivatives (5-7) have been synthesized. The cis-combretastatins were prepared from selective hydrogenation of the corresponding alkyne. Reaction of the alkyne intermediates with benzy